Five Panthers players will feature for New South Wales in the State of Origin decider at Suncorp Stadium next Wednesday night.
Fullback Dylan Edwards, winger Brian To'o, five-eighth Jarome Luai and back rower Liam Martin have been named to start for the Blues, while Panthers co-captain Isaah Yeo has been selected on the interchange.
Meanwhile, Knights centre Bradman Best, who made his Origin debut in Game Three last year, replaces the injured Latrell Mitchell, while Warriors forward Mitchell Barnett is set to make his debut.
NSW BLUES SQUAD
1. Dylan Edwards (Penrith Panthers)
2. Brian To’o (Penrith Panthers)
3. Bradman Best (Newcastle Knights)
4. Stephen Crichton (Canterbury-Bankstown Bulldogs)
5. Zac Lomax (St George Illawarra Dragons)
6. Jarome Luai (Penrith Panthers)
7. Mitchell Moses (Parramatta Eels)
8. Jake Trbojevic (c) (Manly Warringah Sea Eagles)
9. Reece Robson (North Queensland Cowboys)
10. Payne Haas (Brisbane Broncos)
11. Liam Martin (Penrith Panthers)
12. Angus Crichton (Sydney Roosters)
13. Cameron Murray (South Sydney Rabbitohs)
14. Connor Watson (Sydney Roosters)
15. Isaah Yeo (Penrith Panthers)
16. Mitchell Barnett (Warriors)
17. Spencer Leniu (Sydney Roosters)
Coach: Michael Maguire