Panthers coach Ivan Cleary has named his squad to face Sydney Roosters at Sydney Cricket Ground on Saturday.
With Isaah Yeo ruled out due to a shoulder injury, 20-year-old forward Billy Burns will make his NRL debut as Panther No.592.
Born in Parkes, Burns has progressed through the grades at Panthers since joining the club's premiership-winning SG Ball side in 2016.
Jarome Luai is on the bench after making his return from an eye injury in last week's Canterbury Cup match while Josh Mansour is still sidelined with a back injury.
The Panthers will wear the 2019 Away Jersey.
Panthers v Roosters
Sydney Cricket Ground
7.35pm Saturday 31 August
1. Dylan EDWARDS - sponsored by Lendcorp
2. Stephen CRICHTON - sponsored by Daily Press
3. Dean WHARE - sponsored by Volvo Cars Penrith
4. Brent NADEN - sponsored by AMA Event Management
5. Brian TO'O - sponsored by Fornari's Interior Linings
6. James MALONEY - sponsored by Soneta Plumbing
7. Nathan CLEARY - sponsored by Tuff Mouthguards
8. James TAMOU (c) - sponsored by Signace
9. Mitch KENNY - sponsored by Hertz
10. Moses LEOTA - sponsored by HIX Group
11. Viliame KIKAU - sponsored by Zoo Fitness
12. Liam MARTIN - sponsored by Chemtools
13. James FISHER-HARRIS - sponsored by Stylus Blinds
14. Jarome LUAI - sponsored by Chardon & Abbott Home Loans
15. Spencer LENIU - sponsored by Protech Locksmiths
16. Billy BURNS - sponsored by Potter Automotive
17. Reagan CAMPBELL-GILLARD - sponsored by Bidfood
18. Wayde EGAN - sponsored by CETNAJ Wetherill Park/Rouse Hill
19. Sione KATOA - sponsored by Worldwide Parramatta
20. Hame SELE - sponsored by Fantastic Framing
21. Malakai WATENE-ZELEZNIAK - sponsored by Brightside Music