Panthers coach Ivan Cleary has reduced his squad to face Cronulla Sharks at Panthers Stadium on Friday.
James Maloney and Frank Winterstein have been omitted, with the latter to play in the Panthers Canterbury Cup side against Newtown.
19-year-old playmaker Matt Burton earns his NRL debut at five-eighth while 18-year-old prop Spencer Leniu will make his first NRL appearance off the bench.
The Panthers will wear the 2019 Home Jersey.
Prepare to meet NRL debutant Matt Burton
Panthers v Sharks
7.55pm Friday 9 August
1. Dylan EDWARDS - sponsored by Lendcorp
2. Josh MANSOUR - sponsored by Daily Press
3. Dean WHARE - sponsored by Volvo Cars Penrith
4. Brent NADEN - sponsored by AMA Event Management
5. Brian TO'O - sponsored by Fornari's Interior Linings
21. Matt BURTON - sponsored by Soneta Plumbing
7. Nathan CLEARY - sponsored by Tuff Mouthguards
8. James TAMOU (c) - sponsored by Signace
9. Mitch KENNY - sponsored by Hertz
10. James FISHER-HARRIS - sponsored by HIX Group
11. Viliame KIKAU - sponsored by Zoo Fitness
12. Liam MARTIN - sponsored by Chemtools
13. Isaah YEO - sponsored by Stylus Blinds
14. Sione KATOA - sponsored by Chardon & Abbott Home Loans
15. Spencer LENIU - sponsored by Protech Locksmiths
16. Moses LEOTA - sponsored by Potter Automotive
17. Reagan CAMPBELL-GILLARD - sponsored by Bidfood
19. Jed CARTWRIGHT - sponsored by CETNAJ Wetherill Park/Rouse Hill
20. Stephen CRICHTON - sponsored by Worldwide Parramatta
The life-changing call Leniu almost ignored