Panthers coach Ivan Cleary has named his squad to face Manly Sea Eagles at Panthers Stadium on Thursday.
Naden captained the premiership-winning Panthers NYC side in 2015 and returned to the club this season following stints with Canberra Raiders and Newcastle Knights.
The other centre position will be filled by Isaah Yeo, who has overcome a shoulder injury, while James Maloney returns following his one-game suspension.
21-year-old hooker Mitch Kenny has again been granted an exemption to join the team with Wayde Egan still sidelined with a shoulder complaint.
The Panthers will wear the 2019 Home Jersey.
GAMEDAY GUIDE: EVERYTHING YOU NEED TO KNOW
Panthers v Sea Eagles
7.50pm Thursday 30 May
1. Dylan EDWARDS - sponsored by Lendcorp
2. Josh MANSOUR - sponsored by Daily Press
3. Isaah YEO - sponsored by Volvo Cars Penrith
4. Brent NADEN - sponsored by AMA Event Management
5. Brian TO'O - sponsored by Fornari's Interior Linings
6. Jarome LUAI - sponsored by Soneta Plumbing
7. James MALONEY - sponsored by Tuff Mouthguards
8. James TAMOU (c) - sponsored by Signace
9. Sione KATOA - sponsored by Hertz
10. Reagan CAMPBELL-GILLARD - sponsored by HIX Group
11. Viliame KIKAU - sponsored by Zoo Fitness
12. Frank WINTERSTEIN - sponsored by Chemtools
13. James FISHER-HARRIS - sponsored by Stylus Blinds
14. Mitch KENNY - sponsored by Chardon & Abbott Home Loans
15. Tyrell FUIMAONO - sponsored by Protech Locksmiths
16. Moses LEOTA - sponsored by Potter Automotive
17. Tim GRANT - sponsored by Bidfood
18. Hame SELE - sponsored by CETNAJ Wetherill Park/Rouse Hill
19. Kaide ELLIS - sponsored by Worldwide Parramatta
20. Caleb AEKINS - sponsored by Fantastic Framing
21. Liam MARTIN - sponsored by Brightside Music