Chris Lawrence and Tyler Cassel picked up injury concerns as Panthers Bryce Cartwright and Waqa Blake combined to thrash Wests Tigers 23-7.
The scoring started with a perfect right-arm offload from Cartwright which sent Dallin Watene-Zelezniak racing down the sideline to score.
With Tigers skipper Lawrence off early to get his hip iced the Panthers forced a drop out and more beautiful work from Cartwright with an over-the-shoulder pass put Blake over for his first.
Josh Mansour then steamrolled over for to give Penrith a 12-0 half-time lead.
Tigers youngster Tyler Cassel joined his skipper on the sidelines when he went low in a tackle and was concussed early in the second half before Blake cashed in on a simple overlap for his second.
A stunning solo effort from Tim Simona, who chipped ahead for himself twice, finally got Wests on the board with a seven-point try under the posts.
But the red-hot Cartwright jinked down the right touch line then kicked ahead for Blake to bring up his hat-trick on full-time with a seven-point try of his own and seal a 23-7 win.
Penrith Panthers 23 (Blake 3, Watene-Zelezniak, Mansour tries) def Wests Tigers 7 (Simona try)