James Tamou headlines a group of six players who have parted ways with Panthers following the conclusion of the 2020 NRL season.
The departing Tamou is joined by Jack Hetherington, Caleb Aekins, Malakai Watene-Zelezniak, Pat Hollis and Brayden McGrady.
Tamou is headed to Wests Tigers, while Jack Hetherington has signed with the Bulldogs and Caleb Aekins will join Canberra Raiders.
"This has been an extraordinary season for Panthers and each one of these players contributed to that success," Panthers General Manager Rugby League Matt Cameron said.
"From the leadership of James Tamou, to the on-field exploits of Jack, Caleb and Malakai, and the enthusiasm of Pat and Brayden at training, we are grateful for their contributions to our club.
"Regardless of whether they were in the team each week, they sacrificed their personal freedoms to live in our NRL bubble for the best part of six months.
"We thank them for their service to Panthers and wish them all the best with their future endeavours."