The Panthers clash with South Sydney Rabbitohs has been moved to Jubilee Stadium following concerns about the playing surface at Campbelltown Stadium.
The NRL informed Panthers of its decision to relocate the game on Monday afternoon.
The club is now in the process of confirming capacity for sponsors and members to potentially attend Thursday's fixture.
NRL Head of Football Graham Annesley said the game would be played on a fresh surface at Kogarah.
“Campbelltown Stadium has had an extremely heavy workload over the last month, with some games played in wet conditions," he said.
"The staff at Campbelltown Stadium have done an excellent job hosting a number of teams."