Panthers coach Ivan Cleary has finalised his side to face Parramatta Eels at Bankwest Stadium.
21-year-old hooker Mitch Kenny has been named to make his NRL debut off the bench as Panther No.586.
Kenny is a local junior who was a member of the Panthers premiership-winning SG Ball side in 2016, played in the club's Jersey Flegg and Canterbury Cup teams, and was most recently selected in the NSW Residents squad.
Liam Martin and Caleb Aekins have been omitted and will instead play for the Panthers Canterbury Cup side against Wentworthville on Sunday.
The Panthers will wear the 2019 Panthers Indigenous Jersey.
Panthers v Eels
7.50pm Thursday 23 May
1. Dylan EDWARDS - sponsored by Lendcorp
2. Josh MANSOUR - sponsored by Daily Press
3. Dean WHARE - sponsored by Volvo Cars Penrith
4. Waqa BLAKE - sponsored by AMA Event Management
5. Brian TO'O - sponsored by Fornari's Interior Linings
6. Jarome LUAI - sponsored by Soneta Plumbing
7. Nathan CLEARY - sponsored by Tuff Mouthguards
8. James TAMOU (c) - sponsored by Signace
9. Sione KATOA - sponsored by Hertz
16. Tim GRANT - sponsored by HIX Group
11. Viliame KIKAU - sponsored by Zoo Fitness
12. Frank WINTERSTEIN - sponsored by Chemtools
13. James FISHER-HARRIS - sponsored by Stylus Blinds
18. Mitch KENNY - sponsored by Chardon & Abbott Home Loans
15. Tyrell FUIMAONO - sponsored by Protech Locksmiths
10. Reagan CAMPBELL-GILLARD - sponsored by Potter Automotive
17. Moses LEOTA - sponsored by Bidfood