Panthers coach Anthony Griffin has reduced his squad to face Cronulla Sharks at Panthers Stadium on Friday.
James Maloney and Nathan Cleary have been omitted following their efforts for NSW in Origin III.
With Dallin Watene-Zelezniak sidelined with a hamstring injury, fullback Caleb Aekins will make his NRL debut as Panther No.580.
The 20-year-old Kiwi has been a standout performer in the Panthers ISP side this season and recently re-signed with the club until the end of 2020.
Aekins will be the club's sixth NRL debutant in 2018 and will make his debut in the youngest and most inexperienced side to take the field in the NRL competition this year.
The Panthers will wear the 2018 Home Jersey.
Panthers v Sharks
1. Caleb AEKINS - sponsored by Hertz
2. Christian CRICHTON - sponsored by Potter Automotive
3. Waqa BLAKE - sponsored by Annlyn Motors
4. Dean WHARE - sponsored by Col Western Sheds
5. Tyrone PHILLIPS - sponsored by Chardon and Abbott Home Loans
6. Tyrone MAY - sponsored by Elite Sand and Soil
7. Jarome LUAI - sponsored by Protech Locksmiths
8. Trent MERRIN - sponsored by Signace
9. Sione KATOA - sponsored by HIX Group
10. James TAMOU - sponsored by Daily Press
11. Viliame KIKAU - sponsored by Sinclair Ford
12. Isaah YEO (c) - sponsored by Heartland Holden
13. James FISHER-HARRIS - sponsored by OAK Plus
14. Wayde EGAN - sponsored by Irresistible Pools and Spas
15. Corey HARAWIRA-NAERA - sponsored by Chemtools
16. Jack HETHERINGTON - sponsored by Steel Roofing Supply Centre
17. Moses LEOTA - sponsored by ABL Tile and Bathroom Centre
18. Liam MARTIN - sponsored by OAK Plus
19. Kaide ELLIS - sponsored by OAK Plus
20. Tyrone PEACHEY - sponsored by OAK Plus