Panthers has granted Tom Eisenhuth and Oliver Clark an immediate release from their respective contracts with the club to pursue opportunities elsewhere in the NRL.
25-year-old utility Eisenhuth made his lone NRL appearance for the Panthers in 2012 and was a member of the club's premiership-winning Intrust Super Premiership NSW side last season.
Clark, 21, was part of the club's premiership-winning National Youth Competition side of 2015 and has gone on to play 48 games for Panthers in the ISP competition.
"Tom and Oliver have both come through the Panthers development system," Panthers Executive General Manager Phil Gould AM said.
"They are great kids with tremendous attitude to their football and training.
"If we can't provide our players with positions in the NRL, we have never stood in the way of them chasing their dreams and taking up NRL opportunities elsewhere.
"We wish Tom and Oliver the very best of luck and will follow their careers with great interest."