Scans have revealed Waqa Blake suffered a high grade syndesmosis injury in the win against Parramatta on Sunday.
The Panthers centre suffered the right ankle injury after being tackled late in the second half of the game at ANZ Stadium.
Blake will be sidelined for at least four weeks and will meet with a specialist to determine if surgery and a longer recovery period is required.
Blake's replacement at centre will be revealed on Tuesday when Panthers coach Anthony Griffin names his side to face Gold Coast Titans.
