Panthers pair Josh Mansour and Reagan Campbell-Gillard have been named in the Kangaroos side to face France in Canberra on Friday.
The Kangaroos have made six changes from the team that knocked off England in the World Cup opener, with coach Mal Meninga rotating his squad.
Tom Trbojevic, whose brother Jake will this week go under the knife to repair a torn pectoral tendon, has been selected as part of a new-look wingers combination, joining Mansour in the side as Valentine Holmes and Dane Gagai are rested.
Penrith prop Campbell-Gillard will get his first chance to wear the green and gold, partnering Jordan McLean in the front row.
Melbourne duo Cameron Munster and Felise Kaufusi will get their first taste of international football off the bench for the Kangaroos, joining Aaron Woods and David Klemmer as Australia’s substitutes.
Cameron Smith will go past Clive Churchill as the player with the most consecutive Test matches for Australia on Friday night, named in the starting side for what will be his 36th straight appearance in green and gold.
Mansour will fly home on Tuesday night to be with his pregnant wife, who will be induced on Wednesday, but is expected to return later in the week to take his place in the starting side.
Ben Hunt is the only member of the 24-man squad yet to play a game after having been granted the weekend off to get married. He is expected to play against Lebanon in Sydney next Saturday.
Cooper Cronk, Boyd Cordner, Matt Gillett, Dane Gagai, Valentine Holmes and Jake Trbojevic are the six omissions from the team that defeated Wayne Bennett’s England 18-4 in the tournament opener in Melbourne last Friday night.
Kangaroos: Billy Slater, Tom Trbojevic, Will Chambers, Josh Dugan, Josh Mansour, Michael Morgan, James Maloney, Jordan McLean, Cameron Smith, Reagan Campbell-Gillard, Wade Graham, Tyson Frizell, Josh McGuire. Bench: Cameron Munster, Felise Kaufusi, Aaron Woods, David Klemmer. Reserves: Valentine Holmes, Matt Gillett, Dane Gagai, Boyd Cordner