Panthers stars Reagan Campbell-Gillard and Tyrone Peachey will man the phones during Thursday night's Big Change for Little Champions Telethon.

The annual event raises funds for the Starlight Children's Foundation, which works to brighten the lives of seriously ill children and their families.

Starlight runs programs both in and out of hospitals to entertain, engage and empower young people who are facing serious physical challenges.

Tune in to The Footy Show on Channel Nine, 8.30pm Thursday, to participate in the telethon and make your contribution to the fundraising efforts.

Alternatively, visit the fundraising website at bigchangeforlittlechampions.com.au and make your donation online.

Starlight is hoping to raise $650,000 - enough to brighten the lives of more than 16,000 ill children across Australia - so please dig deep and give generously.