They may live together but Penrith's James Segeyaro and Isaac John, and Parramatta's Corey Norman, are set to lock horns in Darwin.

Good mates off the field, the trio will leave their friendship on the sideline when they take to the turf of TIO Stadium on Saturday night.

Norman currently holds the household bragging rights after leading the Eels to a 26-20 victory over the Panthers at Pepper Stadium in Round 12.

The enigmatic five-eighth has played 17 matches for Parramatta this season but has missed the last month with a knee injury. His return is sure to spark an attack which has sputtered its way to three consecutive losses.

After plugging away in NSW Cup most of this season, John gets another opportunity in the NRL after Peter Wallace's season-ending ACL injury. He performed admirably in the Panthers' tough loss to the Rabbitohs last week, with two linebreaks to his name, and will look to repeat the dose against the Eels.

John spoke to Panthers TV about heading to Darwin and tackling his pesky housemate: